Tinospora crispa was used in Ayurvedic and Jamu herbal medicine as a hepatoprotectant, protecting the liver from damage that may occur following exposure to toxins, as well as in Thailand, Philippines. Recent research has demonstrated that a combination of T. cordifolia extract and turmeric extract is effective in preventing the hepatotoxicity which is otherwise produced as a side effect of conventional pharmaceutical treatments for tuberculosis using drugs such as isoniazid and rifampicin.
According to the 1918 United States Dispensatory, the plant has a long history of use in India as a medicine and in the preparation of a starch known as Giloe-ka-sat or as Palo.
Fever, Diaphoretic, Lowers Blood pressure (Hypertension)
T. crispa is not recommended for patients with liver diseases and
concomittant use with other drugs that possess hepatotoxic potential should be avoided.
Therapeutic Uses, Benefits and Claims of Tinospora crispa
- Protecting the liver from damage that may occur following exposure to toxins
- Intestinal worms
- Tropical ulcers
Anti-inflammatory, antioxidant, antiallergic, hepatoprotective, antithrombotic, antiviral and anticarcinogenic activities.
" Two triterpenes are extracted from the stem of T. crispa namely cycloeucalenol and cycloeucalenone.T. crispa stem contains: flavones O-glycosides (apigenine), picroretoside, berberine, palmatine, picroretine and resin. Flavonoids are naturally occurring polyphenolic compounds ubiquitously found in plants. The health benefits of flavonoids attributed to polyphenols is usually linked to two properties namely inhibition of certain enzymes such as xanthine oxidase and antioxidant activity. They have long been recognized to possess anti-inflammatory, antioxidant, antiallergic, hepatoprotective, antithrombotic, antiviral and anticarcinogenic activities. Based on the traditional uses of T. crispa, there has been a substantial increase in the sales of this part of the plant by certain pharmaceutical companies as capsules containing this natural product to treat fever, hypertension, as a diaphoretic tonic and antihyperglycemic agent. "
Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats
Farkaad A. Kadir, Faizah Othman, Mahmood Ameen Abdulla, Farida Hussan, and Pouya Hassandarvish
Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
Middleton E Jr, Kandaswami C, Theoharides TC.
Chebeague Island Institute of Natural Product Research, Chebeague Island, Maryland, USA.
" Tinospora crispa is a medicinal plant used as a remedy for patients with diabetes mellitus in Malaysia. Tinospora crispa was found to have ananti-hyperglycemic effect in animals. The hypoglycemiceffect of Tinospora crispa is mediated by increasing insulin secretion from isolated rat andhuman islets of Langerhans. Tinospora crispa iscommonly used in diabetic patients in Thailandas well. Toxicological study of crude extract ofTinospora crispa revealed no obvious adverseeffects. "
Randomized Controlled Trial of Tinospora crispafor Additional Therapy in Patients withType 2 Diabetes Mellitus
Chawanya Sangsuwan MD*, Suthipol Udompanthurak MSc**,Sathit Vannasaeng MD*, Visanu Thamlikitkul MD*
* Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
** Department of Research Promotion, Faculty of Medicine Siriraj Hospital, Mahidol University
Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract.
Noor H, Ashcroft SJ.
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, UK.
Effect on Blood Sugar Level and Safety of Tinospora crispa in healthy Thai Volunteers
Sadudee Rattanajarasroj* Theerawut Pinthong* Paijit Warachit** Jaree Bansiddhi* Malee Bunjob* and Yenchit Techadamrongsin1
*Medicinal Plant Research Institute **National Institute of Health Department of Medical Sciences , Tiwanond Road, Nonthaburi 11000, Thailand
Lowers Blood pressure
"From these results we suggest that T. crispa extract possesses at least three different cardiovascular-active components that act directly via (1) β2-adrenergic receptors to cause a decrease in blood pressure, and β1- and β2-adrenergic receptors to cause an increase in heart rate, (2) α-adrenergic receptors to cause an increase in blood pressure and heart rate, and (3) a non-adrenergic and non-cholinergic pathway to cause a decrease in MAP and heart rate. These findings provide scientific support for the tradition of using this plant to modify the actions of the human cardiovascular system"
Effects of an n-butanol extract from the stem of Tinospora crispa on blood pressure and heart rate in anesthetized rats
Siwaporn Pramana, Michael J. Mulvanyc, Yves Allenbachd, Andrew Marstond, Kurt Hostettmannd, Poungpen Sirirugsab and Chaweewan Jansakul
Department of Physiology, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
Department of Pharmacology, Aarhus University, Aarhus, Denmark
Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, CH-1211 Geneva 4, Switzerland
Anti - Malaria
"In vitro and in vivo studies revealed that Malaysian medicinal plants, Piper sarmentosum, Andrographis paniculata and Tinospora crispa produced considerable antimalarial effects. Chloroform extract in vitro did show better effect than the methanol extract. The chloroform extract showed complete parasite growth inhibition as low as 0.05 mg/ml drug dose within 24 h incubation period (Andrographis paniculata) as compared to methanol extract of drug dose of 2.5 mg/ml but under incubation time of 48 h of the same plant spesies. In vivo activity of Andrographis paniculata also demonstrated higher antimalarial effect than other two plant species.pport for the tradition of using this plant to modify the actions of the human cardiovascular system"
Antimalarial activity of extracts of Malaysian medicinal plants
Nik Najib Nik A Rahmana, Takahisa Furutab, Somei kojimab, Kikuchi Takaneb and Mustafa Ali Mohd
Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Department of Parasitology, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan
Item Code :Tinospora crispa:Anti Diabetic Fever Herbal Health
Manufactured : Thanyaporn Herbs
Size :100 capsules per bottle
Direction :Take 2 capsules, two times each day with water before mealtimes.
Tinospora crispa Botanical Extract
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